New approaches to the treatment of sepsis.

Neonatal Sepsis: An Update

Sepsis is the most common cause of neonatal mortality. As per National Neonatal-Perinatal Database (NNPD), 2002-2003, the incidence of neonatal sepsis in India was 30 per 1000 live births. Signs and symptoms of sepsis are nonspecific; therefore empirical antimicrobial therapy is promptly initiated after obtaining appropriate cultures. The early manifestations of neonatal sepsis are vague and il...

Effect of SeptimebTM as a new natural extract on severe sepsis: A randomized clinical trial

Background: Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate. Methods: In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group ...

New Physical Approaches combined with nanoparticles in Leishmania major Treatment

Introduction: Cutaneous leishmaniasis is a mutual parasitic disease, which is endemic in some countries of the world. The use of common drugs has been restricted because of confirmed side effects and drug resistance. There are still serious challenges in the treatment of CL. Developing new therapeutic methods for leishmaniasis, besides obtaining a prompt treatment response that...

Procalcitonin as a Marker of Neonatal Sepsis in Intensive Care Units

Background: The appropriateness of using serum levels of procalcotonin (PCT) for early diagnosis of newborn sepsis is still controversial. Therefore, the objective of the present study was to compare the usefulness of PCT with those of serum levels of C-reactive protein (CRP) and white blood cell (WBC) counts in the diagnosis and response to treatment of neonatal sepsis. Methods: A total of 47 ...

Clinical Guideline Adaptation for Treatment of Neonatal Sepsis Based on Frequency of Microbial Agents

Background: Sepsis is one of the most important causes of death in infants. The pattern of bacterial agents responsible for neonatal septicemia changes over time. The main aim of the present study was to provide a clinical guideline adapted for treatment of neonatal sepsis based on the frequency of microbial agents in the Neonatal Intensive Care Unit of Alzahra Hospital, Tabriz, Iran.Meth...

New therapeutical approaches for the treatment of malignant Melanoma